tag:blogger.com,1999:blog-4068181788928443311.post5341625327054129494..comments2023-06-28T08:06:10.328-04:00Comments on Medicalmanes.: Second class drugs.Stan Smithhttp://www.blogger.com/profile/03746356231660986013noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4068181788928443311.post-54082977246698208392017-04-20T14:40:09.125-04:002017-04-20T14:40:09.125-04:00Thank you for your comments. When patients compla...Thank you for your comments. When patients complain of the unsatisfactory nature of generic substitutions they are often not taken seriously. I will certainly re-read your article.Stan Smithhttps://www.blogger.com/profile/03746356231660986013noreply@blogger.comtag:blogger.com,1999:blog-4068181788928443311.post-19268080769940294912017-04-15T22:46:27.752-04:002017-04-15T22:46:27.752-04:00Generic and original medications do contain the sa...Generic and original medications do contain the same active compounds but not the same inactive ingredients and these other ingredients can affect absorption and elimination and can themselves causer side effects. As well there is greater batch to batch variability in a given generic medication. Therefore even the same medication from the same generic company can sometimes be less effective if it is a poor quality batch. <br />To be qualified as equivalent to the original medication a generic must be between 80-125% of the original on several parameters. What this means is that the variability between one generic and another can be even greater if one is near 80% and the other near 125%. Pharmacists can change between one generic to another without informing the patient or physician so this can be a real issue.<br />For a further discussion of the issues especially as they relate to psychortropic medications please see my paper: Switching from Brand-Name to Generic Psychotropic Medications: A Literature Review. Julie Eve Desmarais, Linda Beauclair & Howard C. Margolese: CNS Neuroscience and Therapeutics 2011; 17:750-760.Anonymoushttps://www.blogger.com/profile/17159546420017931259noreply@blogger.com